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View of the Mission Basilica San Diego de Alcalá facade in a state of deterioration. The San Diego mission is located along the historic El Camino Real, at 10818 San Diego Mission Road, San Diego, CA 92108. Photograph circa 1915.Mission San Diego de Alcala, also known as San Diego Mission, is located at 10818 San Diego Mission Road. It was established on May 14, 1769 and founded on July 16th of the same year by Father Junipero Serra, serving as the headquarters of the Alta California Mission System from 1769 to 1771. This was the first of the 21 missions founded by Serra, and was California's first church. The Mission was originally built overlooking the bay, but remained there only five years as the water supply was not sufficient for sustaining the crops, the soil was not fertile enough, and the American Indians were intimidated by the military.