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Photograph of the Los Angeles Infirmary, as it looked in 1881. This was the second building to house the city's finest hospital, located on Naud Street, opposite the Southern Pacific Railroad Depot. This was a three-story American Mansard-style structure with a wrap-around balcony on the second floor, and numerous windows and doors. Two young girls stand next to a large shrub at the front of the hospital, and several adults stand on the balcony. The Daughters of Charity of St. Vincent de Paul established the first hospital in Los Angeles - the Los Angeles Infirmary, in 1856. It was located in the Sonora Town adobe owned by then-Mayor of Los Angeles, Don Cristóbal Aguilar. Four years later, in 1860, the hospital relocated to 1416 Naud Street, between Ann (named for Sister Ann) and Sotillo Street (though other data indicates the location was 1414 Naud Street, between N. Main and San Fernando Road).